TMG (Trimethylglycine)
Disclaimer: The information on this page is for educational purposes only and doesn't constitute medical advice. Please consult your GP or a qualified healthcare professional before starting any new supplement, particularly if you're pregnant, breastfeeding, taking prescription medication, or managing a health condition.
Cellular Balance & Methylation Support
So you're here because...
Are you feeling low on energy, a bit flat in mood, or just wondering how to properly support your body's cellular repair as you age?
TMG is a quiet, unglamorous supplement that works in the background. It's well worth considering on its own, and if you're already taking NR, it's one of the most important additions you can make to your daily routine.
What we recommend, and why
We recommend TMG by "Welzo" — their Ultra High Purity TMG, a pure capsule form (also known as Betaine Anhydrous) delivering 1000mg per serving.
TMG stands for Trimethylglycine. It sounds incredibly technical, but the job it performs is straightforward and highly important. Your body relies heavily on a cellular process called methylation for many everyday jobs, from producing energy to maintaining your cells and even your DNA.
Think of methylation as one of your body's most fundamental housekeeping systems. TMG acts as an efficient donor, providing the raw building blocks that keep this entire system running smoothly.
Here's why supporting this pathway matters:
Ageing: as we get older, our natural methylation system becomes less efficient. This can contribute to daily fatigue, low mood, slower cellular repair, and a build-up of homocysteine. Homocysteine is a natural by-product your body normally clears away, so higher levels are one of the clearest signs that methylation isn't keeping up, and it's something a simple blood test can check.
The NR connection: this is where TMG becomes essential. When you take Nicotinamide Riboside (NR) to boost your NAD+ levels, your body burns through a large amount of "methyl groups" to complete the conversion. Over time, if you don't replenish those groups, you can deplete your body's natural methyl pool — affecting your liver function, mood, and baseline energy. TMG solves this by donating those vital groups straight back.
If you're taking our NR recommendation, TMG is the responsible, balanced thing to add once you've settled into NR. You'll sometimes see the two sold together in one capsule, but we recommend them separately, so you get the certified form of each and can start one at a time. You can view our NR guide here: NR.Why it's part of our range: methylation matters for everyone, men and women alike, and the demands on it tend to grow from our 40s onwards. For women, the hormonal changes of perimenopause and menopause are thought to add to that demand. We include TMG mainly as the natural partner to NR. As with everything we recommend, start one supplement at a time, so you can tell how each one suits you before adding the next.
Sourcing: why purity matters over trademarks
Unlike some of the other supplements we recommend (like Creapure or Kaneka), TMG doesn't require a specific, patented ingredient name. A properly pure, correctly sourced version of TMG is chemically identical regardless of who makes it.
Instead of a fancy brand name, what matters here is purity and transparency. Cheap, low-quality TMG products often use petroleum-derived chemical betaine, which is a completely different source that you wouldn't know about from a vague ingredient label. We specify Welzo because, in our own assessment, it came out as the strongest TMG product we found on the UK market against exactly these criteria — dose, purity, manufacturing standard, and third-party testing — saving you from having to untangle the sourcing details yourself.
Verified Form: "Welzo Ultra High Purity" — Betaine Anhydrous TMG, 1000mg capsules, third-party tested (60 capsules, a 2-month supply at one capsule a day)
A practical note on the capsule format
TMG is highly water-soluble and boasts excellent natural bioavailability — it doesn't need to be wrapped in expensive liposomes or oils to reach your cells effectively. A single 1000mg capsule delivers a consistent, pre-measured dose without the strong taste and smell that pure TMG powder is known for, which is a genuine practical advantage for a supplement you're taking daily.
How to take it
Timing: take your TMG in the morning. If you also choose to take NR, you can take them together, as morning suits both.
Taking it: swallow your capsule with a glass of water, the same as any other supplement — no mixing or measuring required.
Food: food isn't required for absorption, but taking it alongside your breakfast is perfectly fine if you prefer.
Worth knowing
Cholesterol: the primary detail to be aware of with TMG is your daily dose. Very high clinical doses (above 6 grams a day) have been linked to mild increases in LDL ("bad") cholesterol in some individuals. At our recommended standard supplementation doses, this isn't a concern — but if you're actively managing your cholesterol, it's always worth a quick mention to your GP.
Grapefruit juice: unlike some heart or liver supplements, TMG doesn't interact with grapefruit juice.
Pregnancy & breastfeeding: avoid unless a qualified healthcare professional specifically advises otherwise.
Storage: store your capsules somewhere cool and dry, away from direct sunlight or a heat source like an oven or a steamy bathroom cabinet.
Building up in the system: no, TMG doesn't accumulate to toxic levels. It's completely water-soluble, meaning your body takes what it needs to support your cells and flushes any extra out naturally. Think of it more like a vital daily nutrient than a pharmaceutical drug.
Patience: TMG works quietly in the background rather than giving you an obvious, noticeable lift. Most people don't feel it working directly, and it's often the kind of supplement you only notice when you stop. Everyone responds differently, so give it 4 to 6 weeks of consistent daily use, on its own or alongside NR, before reviewing how you feel.
Do you need to take a break?
No. TMG is perfectly safe for continuous daily use. Because it's a fundamental building block your body needs constantly, cycling on and off is unnecessary.
Price & where to buy
£14.99 (around £7.50 a month at one capsule a day)
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Verified for purity & price: 30 October 2026
A note on results
Everyone responds differently to supplements. We can't promise what this will do for you specifically — only that it meets our sourcing standard.
Before you begin, it's well worth reading our guide on things that can affect how your body absorbs supplements
Track it yourself
Since everyone responds differently, we'd suggest keeping a simple note of how you feel over the first few weeks — mood, energy, general balance. It's the easiest way to know if something's actually working for you, not just whether you hope it is.